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KMID : 1123920110250020275
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 2 p.275 ~ p.279
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Anti-inflammatory Effects of Saussurea Lappa Extracts in Murine Macrophages
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Lee Min-Suk
Ryu Do-Gon
Kwon Kang-Beom
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Abstract
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In order to validate the use of Saussurea Lappa as an anti-inflammatory drug in the traditional Korean medicine, I have investigated the effects of water-soluble extract of Saussurea Lappa (ESL) on the production of pro-inflammatory tumor necrosis factor-alpha (TNF-α) in murine RAW 264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS). The extract inhibited dose-dependently TNF-α production without its cytotoxic effect on the macrophages, as measured by enzyme-linked immunosorbent assay, and significantly decreased mRNA levels of TNF-α, as determined using reverse transcription polymerase chain reaction. The extract also inhibited LPS-induced activation of nuclear factor-χＢ, thereby resulting in TNF-α gene expression. These results suggest that ESL may have therapeutic potential in the control of inflammatory diseases mediated by activated macrophages.
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KEYWORD
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Saussurea Lappa, RAW 264.7 cells, tumor necrosis factor-α
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